In the park, grassy savannahs, scrubland and forests (including mountain baobabs and acacias) alternate. In recent decades, vegetation has changed in large parts of the park. The forest and the thicket have been pushed back. Bush savannas and grasslands extend. Despite its problems, the national park is known for its diverse wildlife. He is particularly known for his large birds. Many species of antelope live in the park, including the nyala antelope and the musk ibex. The animals that make up the Big Five include the elephant, buffalo, lion, and leopard.
Compared to the African highlands, the national park is below 400 meters above sea level in what is called Lowveld, here the temperatures are higher and there is less rain. Most of the small rivers in the park carry water only during or after the rainy season. The two large rivers Runde and Save have water all year round. During dry years, the water level of Mwenezi is strongly influenced by dams and water withdrawals from the upper reaches of the river. In the northern part, the Runde river crosses the park before flowing into the Save river shortly before the Mozambican border. This is the lowest point in Zimbabwe, 162 meters above sea level. There magnificent landscapes with sandstone cliffs like the Chilojo cliffs have formed along the rivers.
In the southern part, the railway line from Rutenga to Maputo, Mozambique, crosses the park.